From CNN.com/health

(CNN) -- When Drew Manning stepped out from behind the cardboard cutout of his former fat self on Monday, the audience of "Good Morning America" was appropriately shocked.

The fitness trainer's journey had come to an end after successfully losing more than 70 pounds -- six months after he purposely gained the same amount. "Like it never happened," host George Stephanopoulos said.

"Kind of," Manning said. Both Manning and his wife, Lynn, can attest that a lot actually has changed in the past year. While Manning's body may have returned to its six-pack heydays, his mind, in many ways, has not.

Always a fitness junkie, staying in shape comes naturally for Manning. He's that guy at the gym the rest of us love to hate, the one who likes to use his biceps for pumping iron instead of changing channels, and who prefers sucking down a spinach shake to indulging in a brownie sundae.

Because of that, Manning was a "judgmental" trainer, his wife says. "He would look at someone who was overweight and say, 'They must really be lazy.'

"I was convinced people used genetics or similar excuses as a crutch," Manning writes in his new book, "Fit2Fat2Fit." "You either wanted to be healthy or you didn't."

Defining the new male body ideal

That point of view wasn't helping Manning help his clients. When he failed yet again to push someone over to the light side, he knew something was wrong. In order to better understand the struggles his clients were facing, he had to face them himself.

He gave up the gym and started consuming junk food, fast food and soda. In just six months, he went from 193 pounds with a 34-inch waist to 265 pounds with a 48-inch waist.

Lynn saw the difference in her husband in less time than that. He became lethargic, stopped helping around the house and was less than eager to play with their 2-year-old daughter.

"He was so insecure -- saying 'I'm so fat. I look so horrible,' constantly complaining about how he looks," she said.

Manning says he didn't realize the effects of his weight gain would be more than physical. It altered his relationships and his self-confidence. Returning to the gym after the Fit2Fat portion of his journey made him nervous. The fact that he had to do push-ups on his knees was almost humiliating.

"The biggest thing [I learned] is that it's not just about the physical. It's not just about the meal plan and the workouts and those things. The key is the mental and the emotional issues. I realized those issues are real."

Of course, Manning had his critics. Experts said that his stunt was dangerous. His blood pressure and cholesterol shot up with such dramatic weight gain. But Manning has no regrets. The followers on his website have encouraged him with their own tales of weight loss.

"We see the success stories of people losing all this weight, but it's more common now," he says. "To see someone do it in reverse on purpose -- it's mind blowing. A balance of craziness and inspiration."

Manning suffered through soda deprivation headaches and food cravings on his way back to fit. The journey was easier for him than for most, he'll admit, but he's eager now to provide tips for others to follow in his footsteps.

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From CNN.com/health

Chicago (CNN) -- Doctors who treat breast cancer patients are very excited about an experimental drug that presents a whole new way of knocking out cancer cells.

The drug, trastuzumab emtansine, commonly referred to as T-DM1, appears to be superior to the standard treatment for women with advanced HER2-positive breast cancer. Researchers are presenting the results of a large three-year clinical trial Sunday at the 2012 American Society of Clinical Oncology conference in Chicago.

It's a combination of the targeted drug trastuzumab (the "T" in T-DM1), better known by the brand name Herceptin, and a very powerful chemotherapy drug called emtansine (the "DM1" part). The drug is designed to work when Herceptin alone no longer can keep the cancer in check.

New drugs may help immune system fight cancer

"It's a brand new way of treating HER2-positive breast cancer," said the lead study author, Dr. Kimberly Blackwell. "This will offer a very important therapeutic option for patients faced with HER2-positive metastatic breast cancer."

 

Testing for breast cancer genes

Knitting breasts for cancer patients In this combination drug, Herceptin is delivering the chemo drug to the cancer cell. Blackwell likens it to being used like a carrier pigeon that delivers the DM1 drug, which is what kills the cancer cell.

DM-1 is too toxic to deliver directly into the bloodstream like other chemotherapy drugs. So the Herceptin part of T-DM1 homes in on the cancer cells (sparing other healthy cells) and delivers the powerful DM1 chemo drug into the cell.

About 20% to 25% of women with breast cancer have HER2-positive breast cancer, a particularly aggressive and deadly form of the disease that was very difficult to treat until the FDA approved Herceptin in 1998, revolutionizing how this type of cancer was treated.

Herceptin is an engineered antibody that attaches to the surface of the cancer cell and blocks signals in the cell that tell the cancer to grow. It also boosts the patient's immune system to help fight the cancer.

But in some patients, the cancer comes back, and Herceptin eventually stops working. That's when doctors prescribe a combination of the drugs capecitabine (brand name Xeloda) and lapatinib (brand name Tykerb), which has had its successes.

In this clinical trial, nearly 1,000 patients were divided into two groups: One got the standard capecitabine plus lapatinib treatment; the other group got the experimental drug.

Women getting T-DM1 had 9.6 months of progression-free survival, the time between starting the treatment and the cancer getting worse again, compared with 6.4 months in the standard therapy group. That's a median improvement of three months.

This may not seem like a long time, but as Dr. Eric Winer of the Dana-Farber Cancer Institute in Boston explains, it means a lot to the individual patient.

"I've had patients on this drug for one, two, three years," he explained. Winer says that if a patient gets an additional three months before the tumors start growing again each time she goes through a treatment cycle, that can add up to almost a year.

Some doctors don't know long-term side effects of cancer care

Blackwell says that after two years, 65% of women getting T-DM1 were still alive, compared with 48% in the control group.

And even though this drug is not a cure, many oncologists call these trial results a "huge deal."

That's because another significant benefit with T-DM1 was the lack of significant side effects and better quality of life. Women on T-DM1 did not suffer the usual and often grueling chemotherapy side effects seen in the other group: diarrhea, nausea, vomiting, painful hand-foot syndrome and hair loss. Blackwell said the types of side effects they did have were the kind only a doctor would notice.

"It really changed their whole outlook on what it meant to be on cancer treatment," said Blackwell, who treats patients at Duke University. She added that seeing this benefit for her patients was incredibly rewarding as a breast cancer doctor. This is the first group of (breast cancer) patients where we have to worry about fixing their hair for media interviews. It's huge deal for these patients."

"It's producing very promising results, and as someone who sees a ton of patients, what I'm really excited about is the side effect profile," said Dr. Jennifer Litton, who treats breast cancer patients at the M.D. Anderson Cancer Center in Houston but who was not involved in the study. "It's significantly better than most chemotherapy drugs that we're giving.

"This trial is showing pretty impressive results on the tip of the iceberg where immune therapy can take us," Litton said.

Dr. Louis Weiner, director of Georgetown University's Lombardi Comprehensive Cancer Center, agrees, calling T-DM1 a "magic bullet."

"It represents the fruition of a concept that was advocated more than 100 years ago by Paul Ehrlich, the famous immunologist and Nobel Prize winner, who dreamed of creating basically Trojan horses that would be welcomed into the cell but would be dragging something that is very bad for the cell. This is pretty much how T-DM1 works," he said.

"It's a good drug. I think it will be used quite a bit," Winer said.

Right now, only women participating in the clinical trial have access to this new drug, until it gets approved in the United States and other countries.

Genentech, the company that developed T-DM1, says an application for potential approval will be sent to the FDA and the European counterpart, the European Medicine Agence, this year.

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